基于聚吡咯的光吸收特性以及明胶的温敏性螺旋-无规则卷曲结构变化,以明胶和吡咯为原料,采用化学聚合法制备了具有光敏感控释性能的明胶/聚吡咯(Gel/PPy)复合水凝胶,并使用多菌灵为模板药物考察了该凝胶体系对于药物的控释作用。结果表明:聚吡咯可与明胶有效复合,并起到交联剂的作用,增强凝胶的机械强度。温度的升高能够促进多菌灵的释放。在光照3h条件下,该体系可以实现对多菌灵的有效控制释放,且释放率随着交联剂含量的降低而升高。
Gelatin/polypyrrole (Gel/PPy) with photo-sensitive and controlled release properties was prepared by chemical polymerization based on the light absorption characteristics of polypyrrole and the temperature-sensitive spiral-irregular crimp structure of gelatin.The hydrogel was compounded,and carbendazim was used as a template drug to investigate the controlled release of the gel system.The results showed that polypyrrole could effectively compound with gelatin,and acted as a crosslinking agent to enhance the mechanical strength of the gel.Increasing temperature can promote the release of carbendazim.Under the condition of light for 3 hours,the system could achieve effectively controlled release of carbendazim,and the release rate increased with the decrease of the crosslinker content.
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基金资助
中央高校基本科研业务费专项资金(310829161015);大学生创新创业训练计划(S201910710240);陕西省自然科学基础研究计划资助项目(2020JM-226)
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